Changes in Optical Parameters of Myeloma Proteins with Phosphorylcholine Binding
نویسندگان
چکیده
منابع مشابه
Structure-function relations in phosphorylcholine-binding mouse myeloma proteins.
The binding site interactions between the phosphorylcholine (phosphocholine)-binding mouse myeloma proteins TEPC 15, W3207, McPC 603, MOPC 167, and MOPC 511 and the isotopically substituted hapten phosphoryl[methyl-13C]choline have been investigated using 13C and 31P nuclear magnetic resonance (NMR) spectroscopy. Each protein exhibits a unique NMR pattern, but extensive similarities in chemical...
متن کاملCrystals of phosphorylcholine-binding Fab-fragments from mouse myeloma proteins: preparation and x-ray analysis.
Fab-fragments of several phosphorylcholine-binding mouse-myeloma proteins have been prepared by pepsin digestion; two of these, MOPC 167 and McPC 603, gave large crystals from ammonium sulfate solutions. The Fab-fragment from MOPC 167 crystallizes in a hexagonal space group, but does not diffract to a resolution greater than about 8 A. In contrast, McPC 603 crystals (space group P6(3)) diffract...
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15 صفحه اول1948 Idiotopes of Galactan - Binding Myeloma Proteins
Galactan-binding myeloma proteins (GalBMP) 1 of BALB/c mice form a family of closely related immunoglobulins characterized by VK4 L chains and VII 1B H chains (see ref. 1 for classification). The V regions of four of these proteins have been completely sequenced (2-4). Three VK4 regions, XRPC24 (X24), XRPC44 (X44), and TEPC601 (T601), are identical up to position 95, whereas J539 VK4 differs at...
متن کاملStructural, functional, and idiotypic characteristics of a phosphorylcholine-binding IgA myeloma protein of C57BL/ka allotype
An IgA phosphorylcholine (PC)-binding myeloma protein with IgCH allotypic determinants different from those of BALB/c mice is characterized. The myeloma, CBPC 2, was induced in the CB-20 strain of mice which is congenic to BALB/c but differs from it by carrying the A15 allotypic determinant of C57BL/ka mice. Sequence analysis of the CBPC 2 light chain through the first hypervariable region, as ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1974
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)42346-6